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一、基本信息

姓名：李东尧

学历/学位：研究生/工学博士

职务职称：副教授

所在部门：河北农业大学食品科技学院生物工程系

通讯地址：保定市乐凯南大街2596号河北农业大学食品科技学院

邮政编码：071001

联系电话：0312-7528423

电子邮箱：lidongyao@hebau.edu.cn

二、学习工作经历

2006.09～2010.06 河北北方学院 食品科学与工程 学士

2011.09～2020.08 江南大学 食品科学与工程 硕博

攻读博士学位期间，主要负责陈卫院士团队生物信息服务器poweredge r910及r920的运维，曾经手几十例肠道/发酵食品体系的菌群多样性分析工作；并协助管理气相与液相色谱、四极杆质谱与orbitrap高分辨质谱等大型仪器。接受过多家培训机构有关多组学联合分析的面授培训，以及illumina与termo fisher scientific等公司有关高通量测序与代谢组学的实验操作与分析软件培训，熟悉perl、python、r语言编程，以及shell脚本等大型运算流程pipeline的搭建。论文影响因子累计77.547，总被引频次达779次；参与2项国家自然科学基金资助课题，主要承担组学及生物信息分析工作。

2020.11至今 河北农业大学 生物工程系 副教授

三、主讲课程及研究方向

1、主讲课程：现代食品生物技术、细胞工程、发酵工程与设备

2、研究方向：食品自然发酵过程中群落结构、功能及代谢网络的演替；发酵食品功能性组分对肠道微生物及人体疾病健康的影响；多组学联合分析、深度挖掘发酵食品新资源

四、代表性论文

1. copper inhibits post-acidification of yogurt and affects its flavor: a study based on the cop operon. journal of dairy science. 2023, 106(2): 897 - 911. (co-first author, if = 4.225)

2. effect of fructo-oligosaccharides on the colonization of lactobacillus rhamnosus as 1.2466^t in the gut of mice. food science and human wellness. 2023, 12(2): 607 - 613. (if = 8.022)

3. niacin inhibits post-acidification of yogurt based on the mining of ldb_rs00370 biomarker gene. food research international. 2022, 162(a): 111929. doi: 10.1016/j.foodres.2022.111929. (co-first author, if = 7.425)

4. mechanism of gastrointestinal adaptability and antioxidant function of infant‑derived lactobacillus plantarum bf_15 through genomics. food science and biotechnology. 2022, 31(11): 1451 - 1462. (co-first author, if = 3.231)

5. global transcriptomic analysis of lactobacillus delbrueckii subsp. bulgaricus atcc11842 reveals the role of ldb_rs05285 in the post-acidification of yogurt. food & function. 2021, 12(19): 9077 - 9086. (co-first author, if = 6.317)

6. potential functions of the gastrointestinal microbiome inhabiting the length of the rat digest tract. international journal of molecular sciences. 2019, 20(5), 1232. doi: 10.3390/ijms20051232. (first author, if = 6.208)

7. microbial biogeography and core microbiota of the rat digestive tract. scientific reports. 2017, 7, 45840. doi: 10.1038/srep45840. (first author, top 100 in microbiology, google scholar 130 citations)

8. lactulose differently modulates the composition of luminal and mucosal microbiota in c57bl/6j mice. journal of agricultural and food chemistry. 2016, 64(31), 6240 - 6247. (co-first author, google scholar 97 citations)

9. metagenomic insights into the effects of fructo-oligosaccharides (fos) on the composition of fecal microbiota in mice. journal of agricultural and food chemistry. 2015, 63(3): 856 - 863. (co-first author, google scholar 94 citations)

10. in vitro fermentation of lactulose by human gut bacteria. journal of agricultural and food chemistry. 2014, 62(45): 10970 - 10977. (co-first author, google scholar 50 citations)